1
Prepare the mouth set
Draw a closed mouth, a relaxed open mouth, a wide vowel, and a rounded shape. Keep the chin and mouth corners aligned between drawings so a swap reads as speech rather than a jumping face. Import them into your chosen 2D setup in Blender and confirm that only the intended mouth is visible.
2
Mark the voice beats
Add the recorded line to the editing timeline and listen to it repeatedly. Mark strong syllables, lip closures, and brief silences. For lip sync, prioritize the sounds a viewer can see: closed lips for sounds such as M, B, and P, followed by a clear opening on the next vowel.
3
Swap and preview
Keyframe visibility or switch drawing frames at the marked beats, according to how your 2D character is assembled. Preview at normal speed rather than judging isolated frames. Hold a pose through a short vowel when it reads well, and return to a resting mouth during pauses instead of cycling constantly.